What You Need to Know About Cosmelan

What is Cosmelan and how does it work?

Cosmelan is a depigmentation agent used to lighten skin. Cosmelan inhibits an enzyme called tyrosinase, which is involved in the manufacture of melanin. Melanin is responsible for the darkening of the skin.

What Cosmelan products are available?

Cosmelan comes in a pack.

Cosmelan 1 - Cream (10g) which contains the following:

Azelaic Acid, Kojic Acid, Phytic Acid, Ascorbic Acid, Arbutine, Titanium Dioxide

Cosmelan 2 – Maintenance Cream (30g) which contains:

Titanium Dioxide, Kojic Acid, Phytic Acid, Ascorbic Acid

Mesoestetic - Hydra Vital Factor K Cream (50ml). This pack includes:

Hydro nutritional cream for face and neck. Hydroviton, Vitamin K, Vitamin E, Amniotic fluid, Glycerine, Silicone oil.

The initial treatment

The initial treatment with Cosmelan is always done in a clinic. The first part involves evaluation of the skin type by the doctor. The cleansing of the skin is done with aqua and an acetone containing product. The cleansing removes dead cells and superficial debris.

After the skin washing, Cosmelan 1 is applied. The mask is left on for a total of 4-8 hours depending on your skin type. Following this, you will be allowed to go home with the mask on. After the initial application time has elapsed, the mask is removed with water and a neutral cleanser.

Immediately following the cleansing of the face, the mesoestetic Hydra-vital factor K cream is applied.

The maintenance stage

The second stage is the home maintenance program. It consists of the daily application of the Cosmelan 2 cream. The cream is applied 2-3 times a day, for the first two weeks following the application of the mask, then once a day from then on. Continual daily use is recommended for the best results.


In most cases, skin blemishes start to disappear within the first week after starting treatment. The darker the skin tone, the longer the time it takes for the spots to disappear. The skin starts to appear shiny and healthy looking in 2-3 weeks. In most individuals dark spots can not be seen in 4-6 weeks.

What to expect after the first treatment

  • The skin will turn red in most individuals and may appear like a sun burn
  • For those who have very sensitive skin, an itchy feeling may occur- which subsides in the next 48 hours
  • Most will feel a slight burning and tightening of the skin - this is normal and part of the process. These symptoms will subside in 24-48 hours
  • To limit the itchy and burning sensation, it is recommended that one apply the mesoestetic Hydra-vital factor K whenever necessary

After the first 48 hours, the symptoms resolve in most individuals. The reddening and skin flaking is soon replaced by normal healthy skin. All the reddish spots fade over the next few days.

Are there any precautions before I can apply Cosmelan?

It must be known if the individual has undergone any previous treatments, especially with glycolic acid. If this is confirmed, one must wait at least a week before using Cosmelan depigmentation treatment.

What should I know about Cosmelan?

The Cosmelan depigmentation treatment initiated at the clinic must be continued at home on a daily basis according to the guidelines indicated. The treatment must not be interrupted under any circumstances, during the whole time prescribed.

Can Cosmelan be combined with other treatments?

No. Cosmelan cannot be combined with any other skin treatment or with other depigmentation treatments, as the results may not be predictable or guaranteed.

What skin features can be corrected by Cosmelan?

  • Areas of aged skin
  • Facial blemished from excessive pigmentation
  • Dark skin spots
  • Melasma
  • Cholasma
  • Acne scars

What parts of the body can be treated with Cosmelan?

  • Face
  • Chest area
  • Abdomen
  • Legs and hands

What are Advantages of Cosmelan?

Cosmelan treatment offers numerous advantages compares to the other available depigmentation products:

  • It is effective in the treatment of melasma
  • It is very effective in the treatment of cholasma
  • The procedure is non invasive and painless
  • The results are rapid
  • Can be applied on all skin types, irrespective of sensitivity
  • It has a very light skin peeling agent and thus has minimal side effects
  • Can be applied throughout the year
  • Effective for individuals with acne scars and red skin blemishes
  • Does not contain caustic chemicals
  • Is safe and effective

What are the disadvantages of Cosmelan?

The treatment is temporary and has to be repeated to maintain the benefits.

It is costly but cheaper than other surgical procedures.

What can one expect after treatment with Cosmelan?

In most cases the appearance of blemishes improves by 95%.

Most individuals will see a significant improvement in their skin color, tone and texture just one week after starting the Cosmelan Depigmentation treatment. New luminous and healthy skin will appear in 3-6 weeks.

Is the skin flaking prolonged?

No, skin flaking is usually seen in individuals with sensitive skin. With time the flaking decreases. However, to decrease skin flaking, one should apply mesoestetic Hydra-vital factor K cream. The cream should be applied every 2-4 hours on the days when flaking is severe.

Is Cosmelan the same as a peeling agent?

No, peeling agents generally use acids to remove unwanted skin. Peeling agents have more side effects and can cause prolonged discomfort. Cosmelan is a depigmetation agent which inhibits the skin from forming melanin, a chemical which darkens skin. Cosmelan is a very light peeling agent. The treatment is painless unlike skin peeling agents.

What happens if I can’t apply Cosmelan everyday?

Missing one day occasionally will not have significant consequences. However, the product is very versatile and can be incorporated into one’s life style. It is not recommended that the Cosmelan be discontinued for long periods-otherwise the skin blemishes will return.

Can Cosmelan be used year-round?

Yes, Cosmelan can be used year round.

Can the skin blemishes or spots return if I stop using Cosmelan?

Yes, unfortunately Cosmelan is only a temporary solution. In order to avoid skin blemishes from returning, it is necessary to apply Cosmelan regularly. When Cosmelan is not used, a sun block should be applied.

What follow up is required after Cosmelan Treatment?

Follow up visits are recommended 2-4 weeks after the beginning of treatment, and monthly after, for a period of 3-6 months. Other follow up is on as needed basis.

What is the cost for Cosmelan?

Cosmelan package costs about $600 - $800.

By DermaNetwork.org Staff
Updated: Jan 30, 2017

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